IntroductionWhile Open Access (OA) journals provide free access to articles, they entail high article processing charges (APC), limiting opportunities for young researchers and those from low-middle income countries to publish OA. MethodsCross-sectional study, evaluating APC and academic impact of full OA (FOA) journals in infectious diseases (ID) and clinical microbiology (CM) compared to hybrid journals. Data were collected from Journal Citation Reports and journals’ websites. ResultsAmong 255 journals, median APC was 2850 (interquartile range [IQR] 1325–3654$). Median APC for 120 FOA journals was significantly lower than for 119 hybrid journals (2000, IQR 648–2767$ versus 3550, IQR 2948–4120$, p < 0.001). FOA journals had lower citation numbers and impact metrics compared to hybrid journals. ConclusionWhile FOA ID/CM journals have lower APCs, they also lower academic impact compared to hybrid journals. These findings highlight the need for reforms in the publication process in view of achieving equitable data dissemination.